Find the answer to the following questions in the uploaded document. (1) What i

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Find the answer to the following questions in the uploaded document.
(1) What i

Find the answer to the following questions in the uploaded document.
(1) What is mismatch repair and why would its functional status have the potential to
impact immune checkpoint blockade therapy? How does this relate to the concept of
MANAs?
(2) What approach do the authors used to address the question of whether mismatch
repair defective cancers are susceptible to PD-1 blockade? 
(3) How many patients were enrolled? Consulting the text and Supplementary Methods,
what were the criteria for enrollment? 
(4) Summarizing the data in Figure 1 and Table S1, what type of response to treatment
did the authors observe? 
(5) What hypotheses were tested in Figure 2A and Figure 2B, how they were tested and
what were the results? 
(6) What was the goal of the analysis in Figure 3?
(7) What are the implications of this study?

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